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One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

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doi: 10.3389/fmed.2023.1124275

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Consistent administration helps build up your body's B12 levels, supporting the formation of red blood cells and maintaining nerve health over time