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Cardiologists treating patients with atherosclerotic cardiovascular disease are increasingly initiating semaglutide as a cardiovascular risk modifier, adding an estimated 4.8 million new commercial GLP-1 patients annually

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These medications have clear data on long-term effects, including sustained weight loss, improved metabolic markers, and tolerability patterns

Translating these mechanistic insights into targeted therapeutic strategies across diverse disease contexts, from cancer to neurodegeneration, constitutes a pivotal future challenge, requiring interdisciplinary collaboration and innovative experimental approaches

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In a French longitudinal cohort study conducted with approximately 64,000 women, the patients were followed up for 6 years [157]