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N Engl J Med 349:1349 Oct
As your body gets smaller, your calorie needs decrease, which naturally slows the rate of loss
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Ipamorelin copies ghrelin and binds the GHS-R1a (ghrelin) receptor on the same gland
In the SURMOUNT-1 trial, patients without diabetes treated with tirzepatide 15 mg achieved a mean weight reduction of 16.0% at 72 weeks [22], while semaglutide 2.4 mg in the STEP-1 trial yielded a 14.9% reduction over a similar period (treatment regimen estimand) [23]
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