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Clin Nutr Exp
Unlike nicotinic acid (niacin), niacinamide does not have significant lipid-modifying effects and does not share the same interaction profile
This pattern suggests that with repeated dosing, nonspecific behavioral effects such as malaise or sedation may diminish, potentially reflecting pharmacodynamic adaptation or increased tolerability
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This process requires the involvement of protein disulfide isomerase (PDI), ER redox protein 1 (ERO1), and GRP78 chaperone protein
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