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Together, these results support direct intracellular redox buffering and mitochondrial protection in vitro
17-19 The CAROLINA and CARMELINA studies of linagliptin demonstrated CV safety, but results have not yet been made available (Clinicaltrials.gov identifiers: NCT01243424 and NCT01897532)
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Alternative and non-mutually exclusive mechanisms may involve favorable effects on basal energy expenditure [57] or on the choice of less energy-rich foods consumed in free-living conditions [58], although these latter hypotheses remain to be validated in clinical studies
Its a unique amino acid because its not used to form proteins, unlike many other amino acids (such as l-carnitine, leucine, lysine, methionine or tryptophan), and is not used to make enzymes
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