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Choline diet and its gut microbe-derived metabolite, trimethylamine N-oxide, exacerbate pressure overload-induced heart failure

Mechanistically, TMAO disrupts myocardial calcium homeostasis through two distinct pathways: direct elevation of intracellular Ca 2+ concentration and promotion of SERCA2a (sarco/endoplasmic reticulum Ca 2+ -ATPase) autophagic degradation, which attenuates sarcoplasmic reticulum Ca 2+ reuptake capacity (Lei et al., 2025)

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Anyone with a history of cancer should avoid the therapy unless their specialist approves it

There are general recommendations for safe use of glutathione, but the ideal dosage varies from person to person based on their health condition

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