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Based on current clinical trial data, tirzepatide (Zepbound/Mounjaro) at the 15 mg dose produces the highest average weight loss approximately 2022% of body weight, or around 48 lbs on average in the SURMOUNT-1 trial
What happens if microdosing does not work for you Not everyone responds to microdosing
Because insulin release is glucose-dependent, GLP-1 promotes insulin mainly when blood sugar is elevated, which is part of why the pathway is so attractive as a therapeutic target
2020;98(4S):S1-S115
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