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The effectiveness depends on dosage, formulation, and medical supervision

This is especially important for leaner individuals who may not have a thick fat layer over the thigh

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Athletes look for methods that may help them bounce back after hard sessions, reduce the sense of fatigue, and stay consistent over time

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However, in case of persistent and/or larger ER stress prevailing over the cellular defensive mechanisms, cell injury and activation of various pro-apoptotic signaling pathways take place (Oyadomari and Mori, 2004