However, as this was an observational target trial emulation conducted in a predominantly male Veterans Affairs population, the results support but do not establish causality and may have limited generalisability to broader populations, particularly women and non-veteran groups
These investigations have provided valuable insight into the mechanisms governing growth hormone physiology
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Experts say there are plausible albeit unconfirmed explanations, noting for example that GLP-1 medications may interfere with the efficacy of oral contraceptives or increase fertility in women because they help with weight loss
Similarly, the LEADER trial with liraglutide showed a numerically higher, though non-significant, rate of diabetic retinopathy events compared to placebo (HR, 1.15