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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect
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There was no consistent pattern in the method used across the studies in the different brain regions
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Note: You may notice ascorbic acid listed at the bottom of the ingredient list for this product
For example, a study should not claim a calcium mechanism unless calcium was measured, and it should not claim a cAMP mechanism unless cAMP or a closely linked marker was measured
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