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In addition, in the study of oxidative stress injury in cochlear spiral ganglion neuronal cells (SGNs), it was found that when GPX1 is knocked out, the oxidative stress damage of SGNs by peroxynitrite is aggravated, resulting in loss of SGNs and loss of hearing (Wang et al., 2022)

10.1016/S0140-6736(05)66456-2