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Because of how semaglutide changes the way the body digests food, it can cause changes in bowel movements

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In the meantime, it is important to monitor the long-term safety of the incretin agents as regards pancreatitis, C cell hyperplasia and medullary thyroid cancer [18]

The study was published February 25, 2026, in The Lancet Diabetes & Endocrinology

Patients with pre-existing gastroparesis or severe gastric motility disorders should consult their physician before starting semaglutide, since further slowing of stomach emptying could worsen symptoms

This delayed emptying could theoretically affect the absorption of oral medications, including ondansetron tablets