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We found that Gclc ablation prevented the formation of T1 B cells by 2 weeks of age, indicating that a block in the B cell differentiation process occurred at the very early stage in the spleen (Fig
[Note: RBCs are totally dependent on the pentose phosphate pathway for their supply of NADPH because, unlike other cell types, RBCs do not have an alternate source for this essential coenzyme.] Additional enzymes, such as superoxide dismutase and catalase, catalyze the conversion of other reactive oxygen intermediates to harmless products (see Figure 13.5B)
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