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Macitentan (10 mg) Class: Endothelin Receptor Antagonist Used for: Pulmonary Arterial Hypertension (PAH) Metabolism: Mainly by CYP3A4 enzyme Major DrugDrug Interactions Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, ritonavir, clarithromycin) Decrease metabolism Increase Macitentan level _ Risk of liver toxicity, headache, edema Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine, phenytoin, phenobarbital, St
It is thin enough to minimize pain but thick enough to draw medication without excessive effort
The higher rates in the diabetes population likely reflect the baseline GI motility alterations common in type 2 diabetes (diabetic gastroparesis, autonomic neuropathy) and the potential for additive GI effects with concomitant metformin use
It is also used in the treatment of fibromyalgia, neuropathy, chronic pain and osteoarthritis
Repeated injections can result in irritation, infection, or tissue damage at the administration site, particularly if sterile techniques are not strictly followed, Roberts says
Presented for research literature review only Baudouin-Cornu P et al
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