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Additionally, the expression of oxidatively modified proteins and lipid peroxidation-derived products, such as 13-hydroperoxy-9Z,11E-octadecadienoic acid and 4-hydroxy-2-nonenal, was significantly increased in the brains of the T21 mouse models
Reduced SAM-to-SAH Ratio A low ratio suggests less effective methylation potential even when a single SAM value appears adequate
Master protocols to study multiple therapies, multiple diseases, or both
TABLE 1 Microbiota-produced glucoraphanin metabolites in ex vivo studies
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