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Direct bonding to the sulfhydryl group of GSH in the cytoplasm has been shown to inactivate cisplatin, for example
Pamela Tambini, an internal medicine physician, stated that "these products are unregulated, and little to no scientific evidence supports their effectiveness." Bariatric surgeon Hans Schmidt noted that supplements "do not come anywhere near the strength of the injectable." Dr
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Pulmonary administration enables high local drug concentration, rapid action, and bypasses the first-pass effect, making enzyme-responsive micro-/nanoparticles an attractive strategy for site-specific treatment in the inflamed lung 78
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