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TREX2 degrades cytosolic DNA, repressing cGAS-STING activation, leading to less apoptosis of tumor cells and downregulated CD8 + T cell infiltration in the TME, ultimately enhancing resistance to immunoblockade therapy [17]

Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer

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Presented for research literature review only Stols L et al