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Three different mechanisms of GST-catalyzed isomerization are known: (i) carbon-carbon double bond shifts, (ii) intramolecular redox reactions and (iii) cis-trans isomerizations 21
The fundamental difference lies in the active chemical mechanism used to target adipose tissue
When BMI and comorbidity thresholds are met for anti obesity pharmacotherapy, GLP-1 agonists are recommended as first line or preferred pharmacologic options because of superior weight loss efficacy and cardiometabolic benefit
Some practitioners hold patients at 10 mg if weight loss trajectory is satisfactory, reserving higher doses for plateaus
Statistical analysis All results were expressed as mean standard deviation (SD), with experiments performed using at least three biological replicates
