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Sequential appetite suppression by oral and visceral feedback to the brainstem
8.1 Challenges in the optimization of multi-receptor agonists Although multi-receptor agonists such as tirzepatide exhibit enhanced effectiveness, their development poses distinct obstacles that need careful attention
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18.2% average weight loss at week 68 was observed in patients in the STEP 4 trial, along with reduced blood glucose levels, improved lipid profile and significant improvements in overall quality of life and health status scores
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