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Lademann, J., & Jacobi, U
Second, the expanding indications for GLP-1 medications beyond weight loss are changing the eligibility landscape
Missing doses or inconsistent injection timing can delay therapeutic effects and reduce overall efficacy
While the long-term safety of ipamorelin has yet to be evaluated, we can surmise that, as a growth hormone (GH) secretagogue, long-term ipamorelin therapy may indirectly produce side effects associated with elevated GH levels
Ozempic was approved in 2017, followed by Rybelsus in 2019, to treat Type 2 diabetes
The STEP 8 trial: direct comparison The STEP 8 trial is the most important study for this comparison because it pitted semaglutide 2.4 mg weekly directly against liraglutide 3.0 mg daily in adults with overweight or obesity but without diabetes
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