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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores
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This is an area where I see the highest level of need among my patients
Liver-directed small interfering RNA (siRNA) therapeutics that silence INHBE are advancing as next-generation anti-obesity agents
CJC-1295/ipamorelin and Sermorelin serve a different role: they elevate growth hormone and IGF-1 systemically to support the broader repair environment rather than targeting a specific injury site
Ensure safe administration to prevent complications
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