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Methotrexate was noninferior to prednisone with regard to the primary end point, with an adjusted between-group difference of 1.17 percentage points (95% CI, 4.27 to 1.93)

The SURMOUNT-1 trial showed participants lost up to 22.5% of their body weight on tirzepatide

We saw that many of our patients with PT had a diverticulum or were missing bone over the sigmoid sinus, which is just downstream from the transverse sinuses. Because CT scans have shown that this sigmoid sinus dehiscence can cause PT, we started doing operations to reconstruct the sigmoid sinus or reduce the diverticulum

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Its use is considered illegal in many countries, and it is often sold on the gray market, where product quality and purity are not guaranteed, posing additional health risks

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