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Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors a novel mechanism not shared by any currently licensed UK weight management medicine

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Presented for research literature review only Papini E et al

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Its principal molecular activity is G-actin sequestration via the conserved 'LKKTET' actin-binding motif in the N-terminal region

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Literature both supporting and opposing them are available

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Li et al., 2020)

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