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PMID: 32186677): Increased phototoxic burn tolerance time and quality of life in patients with EPP treated with afamelanotide , published in Orphanet Journal of Rare Diseases (Barman-Aksozen J et al., 2020
With appropriate monitoring and support, most patients successfully navigate the initial treatment period and go on to achieve meaningful improvements in metabolic health
The 88.8% completion rate through 48 weeks confirms that side effects become manageable for the vast majority of patients
again, oxidative stress is believed to be the culprit, with decreased GSTO gene expression resulting in a lowered age of onset for the diseases
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