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Glucagon is usually thought of as a glucose- raising hormone, but in the context of simultaneous GLP-1/GIP agonism the net effect studied in trials was increased energy expenditure alongside strong glycemic control a combination that appears to explain the outsized weight effect observed in the research

485,486 This affects the synthesis of triacylglycerol (TAG), phosphatidic acid (di-P PA), and diacylglycerol (DAG) in the liver