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Mitochondrial Fat Transport
GLP-1 receptor agonists rarely cause hypoglycaemia when used alone, but the risk increases when combined with insulin or sulfonylureasyour clinician may need to reduce doses of these medications
The ATP then blocks the channel which depolarises alpha-cells to a membrane potential range where channels involved in action potentials are inactivated, meaning that calcium influx and subsequent exocytosis of glucagon vesicles no longer occur
GLP-1 therapy can lower systolic and diastolic pressure in some patients, especially those with baseline hypertension
However, its use in very young children (under six) is generally avoided due to the increased risk of side effects and the lack of robust data on safety and efficacy in this age group
