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For example, engineered Escherichia coli Nissle 1917 (EcN) co-expressing anti-PD-L1 and anti-CD9 nanobodies (EcN-Nb) and modified with ICG-loaded zinc-based MOFs to generate EcN-Nb-ZIF-8CHO-ICG (ENZC), can specifically release nanobodies in response to NIR radiation thereby targeting tumor-derived exosomes (TDEs) to alleviate immunosuppression, such as reshaping TAMs to the M1 state and activating more effective and cytotoxic T lymphocytes, ultimately inhibiting tumor proliferation and metastasis (229)
While this process facilitates the clearance of necrotic tissues during the acute phase, persistent activation may lead to chronic inflammation
When the patient chooses to undergo endometriosis treatment, the procedure will be a minimal invasive surgery as described for our study group
We are thankful for the technical services provided by the Transgenic Mouse Models Core Facility of the National Core Facility for Biopharmaceuticals, National Science and Technology Council, Taiwan, as well as the Gene Knockout Mouse Core Laboratory of the National Taiwan University Center of Genomic and Precision Medicine
Bioengineering bacterially derived immunomodulants: a therapeutic approach to inflammatory Bowel disease
doi: 10.1590/fst.24219 79
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