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First, nausea was the most commonly reported GI adverse event across all dose groups but showed a non-monotonic dose-response pattern, peaking at the 12 mg dose (35.9%) rather than the highest dose

Injection pens are designed with dose-setting mechanisms that allow patients to select precise injection amounts

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Preclinical studies investigating KD in HD have primarily used transgenic mouse models, such as the R6/2 mice, which express mutant huntingtin and exhibit progressive motor deficits, weight loss, cognitive impairment, and mitochondrial dysfunction, mimicking central functional and metabolic aspects of HD progression [95, 96]

This suggests the dual mechanism might provide additional appetite control beyond GLP-1 alone

Lilly said people on the next-generation weight loss medication across three different dosages achieved weight loss of 19% to 28%