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RNA-sequencing analysis revealed that the chemical treatment strongly suppressed the expression of programmed cell death- and autophagy-related genes
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Relevant preclinical studies have demonstrated that Ex-4, by acting on GLP-1R, inhibits the PI3K/Akt signaling pathway and increases the expression of Caspase-3 and E-cadherin, thereby promoting apoptosis in human ovarian cancer cells and reducing their metastasis [72]
A.et al (2017)
LK provided a full final draft of the rest of the article, a selection of figures
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