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Additionally, the long-term effects of melanocortin receptor stimulation are unknown, raising concerns about cardiovascular and other systemic effects
Critically, there is no rigorous, comparative research to definitively prove the methods are equally effective or interchangeable
The 2025 review in the International Journal of Molecular Sciences represents the most comprehensive English-language synthesis of this body of research to date
Rizzo G, Lagan AS, Rapisarda AM, La Ferrera GM, Buscema M, Rossetti P, Nigro A, Muscia V, Valenti G, Sapia F, Sarpietro G, Zigarelli M, Vitale SG
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It increases collagen production by up to 70 percent
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