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Although neuroimaging studies have largely examined obesity and AUD phenotypes separately, their findings are generally overlapping and, within the limitations of neuroimagings spatial and temporal resolution, highly consistent with the preclinical studies reviewed above

The glucagon receptor activation in both compounds may help preserve muscle by promoting fat oxidation as the primary fuel source during caloric deficit

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Patients with cardiovascular concerns require careful evaluation because both PT-141 and PDE-5 inhibitors can affect blood pressure