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The insulin assay [17] mixture contained 1 mg/ml insulin and 10 M schistosome Trx1 [18], and enzyme activity was monitored by observing the decrease in A 340 during the first 3 min due to consumption of NADPH ( 340 nm = 6.22 mM 1 cm 1 )
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Table 2 systematically summarizes key research advances in the combined application of TCM formulations and 5-ASA over the past 5 years
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SURPASS-2 results (40 weeks, type 2 diabetes): Tirzepatide 5 mg: -7.6 kg weight loss, -2.01% HbA1c reduction Tirzepatide 10 mg: -9.3 kg weight loss, -2.24% HbA1c reduction Tirzepatide 15 mg: -11.2 kg weight loss, -2.30% HbA1c reduction Semaglutide 1 mg: -5.7 kg weight loss, -1.86% HbA1c reduction SURMOUNT-5 results (72 weeks, obesity): Tirzepatide demonstrated statistically superior weight loss compared to semaglutide 2.4 mg
Cardiovascular benefit: In adults with type 2 diabetes who have established cardiovascular risk, a GLP-1 RA may provide cardiovascular benefit, independent of baseline A1C
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