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Contraindications and Precautions Kidney disease: L-Carnitine metabolism occurs primarily in the kidneys

For instance, if patients present with symptoms such as early hunger or lack of satiety then a GLP-1RA may be appropriate compared with other available treatments that work solely by suppressing appetite or inhibiting fat absorption [23]

Compared to other single agonists, tirzepatide provides better glycemic control [99, 100]

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Excessive calorie restriction, inadequate protein intake, or improper dosing can worsen fatigue, slow metabolism, and intensify thyroid-related symptoms

Neither substitutes for the other