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The peptide N-terminus is highly conserved between GLP-1, exendin-4 and oxyntomodulin, and as such, a large number of receptor contacts are also conserved, whereas these are more divergent when compared with exendin-P5 (Supplementary Table 1)

For chronic conditions, the timeline is longer: early gains within 12 weeks, gradual functional improvement over 48 weeks, major progress within 812 weeks, and best results often after 12+ weeks

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