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Suppression of SNAIL2, a zinc finger protein member of the SNAIL superfamily of epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) commonly overexpressed in pancreatic cancer patients, restored sensitivity of pancreatic cancer cell lines KLM1 and KMP5 to chemotherapy drug gemcitabine through an IGF binding protein 2 (IGFBP2)-dependent mechanism in vitro and in vivo (50)

GSH is synthesized from three amino acids in two ATP-dependent enzymatic steps

Vitamin B12 is essential for producing red blood cells and helps the body absorb iron

Once opened, exposure to air/oxygen increases oxidation risk, and using sterile technique (especially for reconstituted solution) is essential

For instance, ferroptosis inducers such as sulfasalazine and erastin have been shown to significantly inhibit tumor cell proliferation (69), highlighting their therapeutic potential