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By covalent (albiglutide, dulaglutide) or no-covalent (semaglutide) coupling to larger molecules with slow clearance, analogs with even more prolonged activity have been produced so that there are now several once-weekly agonists on the market
The reverse transition is also possible
These are patterns from real-world reports rather than trial incidence rates
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Those taking anticoagulants should monitor carefully given the peptides effects on vascular systems
The main incretin hormones secreted by the epithelial cells of the gastrointestinal track are glucagon-like peptide-1 (GLP)-1 and glucose-dependent insulinotropic peptide, also known as Gastric Inhibitory Polypeptide (GIP), which stimulate the pancreatic cells ( and cells) and regulate insulin secretion with respect to blood glucose concentration (Drucker, 2006)
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