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PMID: 12697696 Khamsi F et al
The effects of microbiome and its metabolites on body functions are complex, and in many studies we have found that the improvement of symptoms before and after treatment is accompanied by a certain change in the microbiome structure, a phenomenon that leads us to think further about the question of whether a drug is effective by targeting a certain stage of the physiological/pathological response directly, or whether a drug is effective by affecting certain signals through changes in the internal environment affecting the structure of the microbiome, or both
Figure 3: Homocysteine (Hcy) follows two pathways in cells: one turns it into methionine, and the other into cystathionine
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
Nature 559, 484485
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