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Archived from the original on 2022-05-12

Both the Evoke and Evoke+ trials were slated to be completed over the course of three years, attempting to confirm superiority of semaglutide versus placebo in the reduction of progression of Alzheimers disease, as measured by the change in Clinical Dementia Rating Sum of Boxes (CDR-SB) score compared to baseline, however after unsuccessful results Novo Nordisk is expected to discontinue the one-year extension plan for the study based on the efficacy results observed in the overall study population

The newest medicine is Mounjari (Tirzepetide)

Further escalation to 2-2.4 mg daily follows after another 2-4 weeks if needed

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doi: 10.1016/j.neurobiolaging.2010.02.014 173 WangXHYangWHolscherCWangZJCaiHYLiQSet al