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a complete cAMPPKA mechanism
StatPearls (US source) states, Patients generally receive lifelong intramuscular (IM) injections of vitamin B12 (typically 1000 g per month)
The isolated mRNA was used to generate dual-indexed cDNA libraries using the NEBNext Ultra II Directional RNA Library Prep Kit for Illumina (New England Biolabs)
In case of TCN1 polymorphisms, severe B12 deficiency at tissue level can occur, which can also lead to megaloblastic anaemia, growth retardation, and neurological complications whereas TCN2 mutations are associated with Alzheiners disease and autoimmune gastritis (inflamed stomach lining)
PMC 374312
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