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Moreover, regarding that GSH is critical in DNA synthesis, while DNA damage is correlated with UC, we can conclude that lycopene exerts its beneficial effect on UC by preventing oxidative-related DNA damage (Yin et al., 2023

Acetaminophen cytotoxicity in HepG2 cells is associated with a decoupling of glycolysis from the TCA cycle, loss of NADPH production, and suppression of anabolism

Degradation of glutathione and glutathione conjugates in plants [PMID: 36651789] Laboratory literature summary: Degradation of glutathione and glutathione conjugates in plants

There is no officially safe maximum limit for humans

The analyses were conducted by fitting GSH, GSH:GSSG ratio, and GPX as continuous variables as well as categorizing them into tertiles

Furthermore, the well documented efficacy of combined folic acid, B6, and B12-vitamin supplementation to reduce hyperhomocysteinemia could enhance GSH activity and reduce oxidative stress (161)