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We further reveal that glutamine provides essential precursors for GSH biosynthesis
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It remains unresolved whether reduced frataxin triggers ferroptosis by inhibiting ironsulfur cluster synthesis enzymes (such as NFS1 and ISCU) and disrupting mitochondrial iron homeostasis, nor is it known how lipid peroxidation products generated during ferroptosis further impair frataxin function and exacerbate ironsulfur cluster assembly defects
Over-the-counter antiemetics like meclizine or dimenhydrinate may help for more persistent nausea, though sedation can be an issue
10.1016/j.pharmthera.2020.107525 49 SmirnovaO
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