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(2024) 68(3):e2300522

To view a copy of this licence, visit About this article Cite this article Coden, K.M., Nguyen, D.K.K., Moorhead, R

Achieving sufficient and sustained drug concentrations specifically at the site of myocardial injury remains a major obstacle for systemically administered agents due to poor pharmacokinetics, rapid clearance, and lack of specific targeting to affected cells ( Significant patient heterogeneity in baseline oxidative stress levels, comorbidities, and genetic predispositions further complicates a one-size-fits-all approach, influencing individual responses to targeted therapies (Zou et al., 2024)

Canadian Employer Plans Covering GLP-1s for Weight Loss Have Nearly Doubled Data from the International Foundation of Employee Benefit Plans (IFEBP) 2025 Pulse Survey shows a significant shift in Canadian employer attitudes toward GLP-1 coverage: 31% of employer plans now cover GLP-1s for weight loss (up from 17% in 2024) 56% cover for diabetes only (down from 66% in 2024) 20% of diabetes-only plans are considering adding obesity coverage Provincial public drug plans still cover semaglutide only for type 2 diabetes not for weight loss

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(2) Tkalcevi VI, Cuzi S, Brajsa K, Mildner B, Bokuli A, Situm K, Perovi D, Glojnari I, Parnham MJ