This is a compound that is sort of like a hormetic compound, or as David Sinclair likes to say, it's a xenohormetic compound
*Correspondence: Do-Hee Kim, [email protected] This article was submitted to Cancer Metabolism, a section of the journal Frontiers in Oncology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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Its cell-penetrating properties allow it to enter cells without transfection or vector delivery, where it directly engages the p53 TAD2 domain to disrupt the FOXO4-p53 complex
It is also the pathway that drives IGF-1 LR3's insulin-like glucose-lowering effect the same mechanism that creates hypoglycemia risk