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Cross-model transcriptomic convergence reveals common molecular signatures of early-life adversity Building on our previous finding that low-dose PFE induces persistent affective deficits and mesolimbic circuit disruption [25], we next examined whether behavioral similarities across prenatal THC, stress, and fentanyl exposures reflected transcriptomic convergence

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Primary APP23 mouse neurons were infected with lentivirus carrying scramble sequence or short-hairpin RNA (shRNA) sequence targeting AMPK, with or without treatment of exendin-4