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In addition, the change in the total score of MMSE-J may not reflect cognitive improvement linearly

Vitamin B12 deficiency is primarily caused by autoimmune pernicious anemia, dietary restrictions such as vegetarian or vegan diets, and medical conditions that interfere with absorption such as celiac and Crohns disease

The theoretical oncological concern associated with telomerase or ALT activation highlighted rather than dispelled by the 2025 finding of telomere lengthening in cancer cell lines remains an open question that has not been adequately addressed by long-term controlled human studies

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When telomeres become critically short, cells enter senescence or apoptosis, contributing to aging

Most side effects are temporary, but severe allergic reactions require immediate medical attention