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Mechanistically, CAR-M cells carrying the FcR signaling domain synergize with CAR-T cells, as inflammatory cytokines secreted by CAR-T upregulate CD86/CD80 expression on CAR-M surfaces, promoting M1 polarization, whereas upregulated costimulatory molecules on CAR-M further activate CAR-T, forming a positive feedback loop that enhances antitumor activity (311)

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Published scientific literature has discussed BPC-157 and TB-500 in relation to peptide biology, molecular signaling pathways, protein interactions, extracellular matrix research, cellular communication models, and analytical peptide chemistry