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Elevated polyamine levels are necessary for neoplastic transformation and tumor progression (Casero et al., 2018)
Neuropharmacology 46 , 404411 (2004)
[16] Surges of secretion during the day occur at 3- to 5-hour intervals
DOI:10.1007/ s13277-013-0778-z [ Links ] 54
Additionally, Candida albicans secretes aspartyl proteinases (SAPs) that degrade mitochondrial structural and metabolic proteins, further impairing mitochondrial integrity and energy production ( Cryptococcus neoformans utilizes a polysaccharide capsule to suppress mitochondrial metabolism in macrophages, decreasing mtROS production and blunting fungicidal activity ( 4.2 Fungal-mediated disruption of mitochondrial bioenergetics and ETC function Mitochondrial OXPHOS serves as a key energy source for immune cell function, particularly for macrophages and dendritic cells engaged in antifungal defense
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