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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64
Effects of gastric inhibitory polypeptide on glucose and lipid metabolism of isolated rat adipocytes
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nevertheless an augmentation of the latter was related to more frequent pain (Saulnier et al., 2011)
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