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Since the progression to invasive PDAC is believed to take more than a decade, the follow-up periods in many cohort studies and randomized controlled trials (where it is typically 12 years) are insufficient to understand the long-term effects

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Metabolomic studies in the preclinical ischemic AKI model have shed substantial light on this issue and demonstrated widespread changes in energy metabolism in the kidney as well as remote organs including the heart and lung 6,15, 16