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Category 2 substances are specifically identified as raising significant safety concerns
57 However, due its aspecific pharmacological properties in targeting GST, the newer GST inhibitors TLK117/TLK199 and NBDHEX may prove to be more promising
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however, the response intensity is difficult to evaluate due to the differences in experimental designs, RPM sources, and purity among studies (Wei et al., 2022)
The discovery of G6PD crystal structures and subsequent analyses provided us with further insights into this enzyme deficiency, since specific mutations can now be plotted on a 3D position in the protein structure
Proapoptotic activity of new glutathione S-transferase inhibitors
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